Commander Shepard's story have finished, but as Bioware said, the universe is massive in mass effect in lore and scale, possibilities of new games are endless. My question is simple:
What kind of game do you want the next game to be, still RPG? Or FPS, Third person action adventure, or even some hybrid?
Any ideas of where the game should focus? As big Mass Effect is, it is always better if there is a clear focus. Where do you want the game to focus on? The smugglers of Omega? C - Sec investigator? Or even a civilian trying to survive the odds?