With better graphics, one can assume. :D
Fallout 3 had quests that were closed off by doing other quests? The only two quests I didn’t do in my first playthrough were Strictly Business and You Gotta Shoot ‘Em In the Head, mostly because my first character wasn’t a dick.
You’re probably thinking of New Vegas, where actions could actually close off other quests since factions mattered instead of karma.