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Every time we see a dog in a game trailer the first thing we think is that the dog is going to die, it's going to be heartbreaking, and it's hard to keep from sighing a bit.
Today, Bethesda actually deflated a bit of the stress of the dog from Fallout 4 with a tweet.
From @BethesdaStudios' Todd Howard: Dogmeat cannot die #Fallout4 #BE3 pic.twitter.com/0hSaF42xoD
— Bethesda Softworks (@Bethblog) June 16, 2015
So there you go. That dog is going to be your friend to the end, or at least until its removed for some narrative purpose that doesn't involve its death.