In Madden NFL 16, Mario Williams has red eyes! So help me, red eyes!
The Buffalo Bills defensive lineman (and Richlands Wildcat) wears red eye contact lenses, noticed in November of the last NFL season. He uses them for a psychological advantage when he's staring into the face of an opposing offensive tackle. Now, his physical dimensions (6-6, 290 pounds) may play a role in the 14.5 sacks he recorded last season (tied for fourth in the league) but he was also wearing the red eyes, so who's to say they didn't also help.
Williams' red peepers also are in Madden NFL 16, and if you zoom in close enough on replays you'll see for yourself. Dustin Smith, Madden's "authenticity guru" for player appearance (equipment preferences and such) said he "pushed hard" for the red-eye option — which is not available in player creation either in the main game or the Connected Franchise career suite. This is solely for Mario Williams. Fellow defensive end Kyle Vanden Bosch (who retired after the 2012 season) also wore red eye lenses but never got the treatment in-game.
@owengood it's only on Mario Williams we have the ability to change eye color on our player heads, he and Vanden Bosch are the only guys— Dustin Smith (@Equipment_Guru) August 29, 2015
And for baseball fans wondering, yes, Max Scherzer's heterochromia (two different-colored irises) is accurate in MLB 15 The Show.