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- Thandie Newton as Maeve and Rodrigo Santoro as Hector Escaton
- Angela Sarafyan as Clementine
- James Marsden as Teddy
- Rodrigo Santoro as Hector Escaton
- Anthony Hopkins as Dr. Robert Ford
- James Marsden as Teddy and Evan Rachel Wood as Dolores Abernathy
- Jeffrey Wright as Bernard Lowe
- Ed Harris as The Man in Black
- Thandie Newton as Maeve
- Shannon Woodward as Elsie and Sidse Babett Knudsen as Theresa Cullen
- Simon Quarterman as Lee Sizemore
- Jimmi Simpson as William
- Evan Rachel Wood as Dolores Abernathy
- Ingrid Bolsø Berdal as Armistice
- Anthony Hopkins as Dr. Robert Ford and Jeffrey Wright as Bernard Lowe