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Resident Evil 2 Leon walkthrough Part 15: West Area, G (Phase 3) boss fight, and escape the lab

Oh yeah, and Tyrant’s back. Of course.

Resident Evil 2 West Area, G (Phase 3) boss fight, and escape the lab Leon walkthrough Capcom via Polygon
Jeffrey Parkin (he/him) has been writing video game guides for Polygon for almost seven years. He has learned to love just about every genre of game that exists.

We’ve explored a lot of Resident Evil 2’s NEST Laboratory and finally have a way to get to the West Area. Now it’s time to go grab that G-Virus and leave without any hassle at all.

Get the G-Virus sample in the West Area

Run around to the back side of the Main Shaft again and use the panel on the left to extend the bridge to the West Area.

Grab the Lab Digital Video Cassette and the Hand Grenade from the corpse in the hall, then continue into the room ahead of you.

Biotesting Lab

Head to the wall and use the Signal Modulator tuned to OSS to power up the room. Watch the Lab Digital Video Cassette and read William Birkin’s Inbox.

Head to the Item Box — you can drop off the VHS and Signal Modulator.

Resident Evil 2 Biotesting Lab Capcom via Polygon

Head into the next room and off to the right. Right before you exit, cut to the left to pick up a Blue Herb. Continue into the hallway beyond. There’s nothing in the lockers, but there is some High-Grade Gunpowder on the counter on the right at the far end.

Bioreactor Lab

Resident Evil 2 Bioreactor Lab Capcom via Polygon

Keep heading west through the decontamination process and cross the bridge through the Bioreactor Lab. In the room on the far side, hit the computer on the left to read the Research Diary. Turn to the right and grab the G-Virus Sample. Head to the attached room to the right.

Grab the High-Grade Gunpowder, Gunpowder (Large), and Red Herb, then visit the Typewriter and Item Box. Things are about to get serious.

Turn around and run back across the Bioreactor Lab. It doesn’t go well.

G (Phase 3) boss fight

After the cutscene, you’ll have to face G — formerly Dr. William Birkin — one last time. This fight is very similar to your first fight with him. There are supplies scattered around the Bioreactor Lab floor to help you out. The only difference are: He’s got a lot more eyes this time, and he throws things. As you’re running around, watch for:

  • Handgun Ammo
  • MAG Ammo
  • Flash Grenade
  • First Aid Spray
  • Hand Grenage
  • Fuel
  • More Handgun Ammo
  • More MAG Ammo
Resident Evil 2 G and one of his three giant, yellow eyes. Capcom via Polygon

For the first bit of the fight, your job is to not get slashed and just keep shooting G in his giant, yellow eyes. He’s got one on his right shoulder, one on his left thigh, and one on his left shoulderblade. Just keep sprint away from him and spinning to target those eyes.

If he tries to lift one of the explosive pieces of machinery around the room, target one of his eyes and pop it. That’ll keep him from throwing a deadly chunk of metal that explodes.

Resident Evil 2 G with his chest eye cluster exposed. Capcom via Polygon

Just keep popping his eyes as they show up again. Eventually, he will fall to his knees and expose a cluster of eyes on his chest. Pump everything you can into those eyes. Your job is to pop all of them. You probably won’t get them all on your first try, so just repeat the process again. The Flamethrower seems to work well here.

Return to Ada

Sweep the floor of the Bioreactor Lab for any supplies you didn’t find or use in the boss fight, then take the lift back up to the walkway above. Sprint all the way back to the Main Shaft.

After the cutscene, take the elevator in the center of the Main Shaft down.

Monitor Room

Resident Evil 2 NEST B3 Monitor Room Capcom via Polygon

As soon as you get off the elevator, grab the First Aid Spray, then continue into the room to trigger another cutscene. Continue through the room and grab the Combat Knife.

Pump Room

Exit the room and go down the stairs on the left. Hit the Typewriter and Item Box one more time, then duck into the room on your left. Follow the walkway around and take the lift down to the floor below you.

There’s a couple Ivy waiting for you down here. Watch for the Blue Herb on your left. Follow the walkway around and go through the door at the far end. Through the door, pick up the Green Herb, then climb down the ladder.

Resident Evil 2 Tyrant again Capcom via Polygon

Just keep following the walkways the only way you can. About when things look like you might actually survive, Tyrant shows up again. Of course.


Sprint past Tyrant and keep winding your way through the fiery underbelly of the NEST. You’ll bump into another zombie or two. You can put the down if you want, or just keep running.

Keep heading the only way you can — there are no branching paths to worry about — until you trigger one more cutscene.

Escape Shaft

When you regain control of Leon, follow the walkway to the right and into the Escape Shaft. Grab the Red Herb, Handgun Ammo, and Joint Plug — there’s an Item Box right here too if you need to free up any space.

Take the Joint Plug over, plug it into the panel ahead of you, and pull the lever.

Super Tyrant boss fight

Resident Evil 2 Super Tyrant is no fun Capcom via Polygon

Facing Super Tyrant is a lot like your previous encounters with Tyrant. You can’t beat him, but you can knock him down for a few precious seconds. You just don’t have a lot of room to run around on this lift and he’s much faster than before.

Resident Evil 2 Super Tyrant is intimidating, but you can still avoid his attacks Capcom via Polygon

Keep moving and try to keep some room between you and him while you shoot him as much as possible. He’ll telegraph when he’s going to do a rushing or jumping attack, so watch him closely.

Eventually, you’ll trigger another brief cutscene. Afterward, sprint to the Anti-Tank Rocket, equip it, and put one in Tyrant’s face.

The end

When the elevator comes to a stop, a crowd of zombies will pile through a door at you. You could slowly pick them off with one of your guns or make a hopeful throw with a grenade … or you could just fire one more of your new Anti-Tank Rockets into the doorway.

Head through the door and watch the credits roll.